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They would not require constant monitoring and adjustment of dosages, nor would they have such a narrow effective range.

Many regulators and physicians believed these newer drugs represented an overall improved safety profile. But newer drugs like Pradaxa and Xarelto were initially launched without antidotes, causing a number of serious bleeding events and deaths. Reversal agents for old-style blood thinners like warfarin and heparin have existed since the early 1900s. Current Anticoagulants Didn't Always Have Antidotesīlood thinners currently available in the United States have antidotes, but that wasn't always the case. They would have to weigh the advantages of decreased clotting and stroke with the small but real risk of experiencing a life-threatening bleeding event with no available remedy.

Without a way to reverse the effects of anticoagulants, patients using the therapy would be left in a very precarious position. Though they can and do help many patients, anticoagulants can cause serious bleeding.